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Indication & Dosage |
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| Precautions |
Gradual withdrawal, elderly, severe renal disease, impaired hepatic function, allergy or bronchial asthma, systemic lupus erythematosus, acute gout, diabetes mellitus, cardiac arrhythmias, pregnancy, lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Electrolyte imbalance, pancreatitis, jaundice, diarrhoea, vomiting, cramps, constipation, gastric irritation, nausea, anorexia, aplastic anaemia, agranulocytosis, leukopaenia, haemolytic anaemia, thrombocytopaenia, anaphylactic reactions, vasculitis, resp distress including pneumonitis and pulmonary oedema, photosensitivity, fever, urticaria, rash, purpura, hyperglycaemia, glycosuria, hyperuricaemia, vertigo, paraesthesias, dizziness, headache, restlessness, renal failure, renal dysfunction, interstitial nephritis, erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopoecia, transient blurred vision, xanthopsia, impotence. |
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| Adverse Drug Reactions |
Severe hypotension. |
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| Interactions |
Diuretics decrease renal clearance of lithium. Hypnosedatives, alcohol, antihistamines may cause excessive drowsiness. In combination with alcohol, barbiturates, or narcotics risk of orthostatic hypotension is increased. Antihypertensive gives additive effect. Absorption is reduced with cholestyramine and colestipol resins. Hypokalaemia is observed with corticosteroids. Tubocurarine responsiveness is increased. NSAID reduces the diuretic and natriuretic effect. |
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